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Stanley Hazen

Co-section head of Preventive Cardiology, Cleveland Clinic

Cardiologist and researcher whose Cleveland Clinic team first showed that gut bacteria make TMAO when they digest nutrients such as choline and carnitine. His lab has tied TMAO to heart attack, stroke, heart failure and kidney disease risk and works on drugs that block its production. He is named on Cleveland Clinic patents on heart tests and treatments and has reported industry consulting and research funding.

gut microbiometmaoheart diseasepreventive cardiology

WHAT TO WATCHWhether drugs that block TMAO production in the gut move into human trials.

ON THE WIRE

Every story about Stanley’s work.

Profile sources

  1. 1
    TMAO Shown to Be a Modifiable Risk Factor for Atrial Fibrillation Cleveland Clinic
  2. 2
    Study by Cleveland Clinic, Tufts University Highlights Potential for Using TMAO -- a Digestive By-Product -- to Predict Heart Failure Risk | Newswise newswise.com
  3. 3
    New Class of Drugs May Reduce Heart Risk by Targeting Gut Microbes lerner.ccf.org
  4. 4
    Gut microbial trimethylamine N-oxide generation promotes risk of atrial fibrillation via muscarinic receptor-mediated autonomic dysfunction - PubMed PubMed