Every new development in aging science, biohacking and new therapies, found as it happens, read at the original source and labeled by how strong the evidence is. We don’t tell you what works. We show you what was found.
Recursion says its daily pill reduced polyp tissue in most people with an inherited colon polyp disease and plans a larger trial, aimed at approval, in the second half of 2027.
Recursion says its daily pill reduced polyp tissue in most people with an inherited colon polyp disease and plans a larger trial, aimed at approval, in the second half of 2027.
In a 12-week test in 48 adults whose MS slowly worsens without flare-ups, the lower dose of a nasal antibody spray reduced a brain-scan sign of inflammation compared with a dummy spray.
Australia's medicines regulator approved Novo Nordisk's daily Wegovy pill, a tablet version of the weekly weight-loss shot, with sales expected to start in Australia by the end of the year.
Doctors in Germany report that a single infusion edited the faulty gene behind alpha-1 antitrypsin deficiency in a 66-year-old man. About half the gene copies checked in his liver were corrected.
An experimental treatment uses immune cells taken from a patient's own tumor, then switched on with an approved drug. Its trial is now recruiting new groups of melanoma patients.
A review presented at the Menopause Society's meeting found three small trials in which women felt they thought more clearly on ADHD drugs, though lab tests showed no gain.
Servier says sevasemten, a pill it bought from Edgewise for $1.55 billion, did not slow Becker muscular dystrophy in an 18-month trial against a dummy pill.
Researchers in China compared testicle tissue from two younger and two older men, then found that boosting one protein in lab-grown cells sped up signs of aging.
A newly registered study will give adults aged 45 to 80 capsules made from donor stool, or a dummy pill, and track a blood-based measure of how fast they are aging.
In two large trials of about 2,000 adults, a daily Novartis pill for multiple sclerosis led to fewer relapses and fewer new brain spots on scans than the older pill Aubagio.
A Mayo Clinic records study found midlife women using menopause hormone therapy lost slightly more weight on Ozempic or Wegovy. It cannot show the hormones caused the difference.
A study of nearly 90,000 French adults linked a sugar that humans cannot make, found mainly in beef and lamb, to type 2 diabetes. The link faded once total red meat was counted.
In past heart scans from 27,382 patients, an AI's measure of how well the heart pumps was slightly better than experts' at spotting who was more likely to die.
In a trial of 8,323 people with heart disease, Novartis and Ionis's drug lowered Lp(a) but did not significantly reduce a combined measure of heart events. Full results are still to come.
An early test of a targeted drug carrying a different cell-killing cargo shrank tumors in half of 10 heavily treated HER2-positive breast cancer patients who had already received Enhertu.
South Korea's OliX filed to start a 64-person US trial of an eye injection that aims to switch off an inflammation signal behind geographic atrophy, a form of dry macular degeneration that steals central vision.
US obstetrician-gynecologists replaced their 2014 advice on hot flashes, night sweats, sleep and mood, backing hormone therapy for many women and listing newer non-hormone choices.
Researchers found a set of blood proteins that shift during menopause and were linked to poorer thinking and a modestly higher Alzheimer's risk in older women.
In a trial of 744 people aged 65 or older with a moderately narrowed heart valve, replacing it early meant fewer deaths or heart failure events over two years than waiting.
US regulators have agreed to review uniQure's one-time brain gene therapy for Huntington's disease on a faster track, with a decision due by May 1, 2027, the company said.
Sixteen breast cancer survivors said their thinking felt clearer after eight weeks on oxaloacetate. With no comparison group, the study cannot show the supplement caused the change.
Enlivex says 79.2% of knee arthritis patients aged 64 and up who got three shots of its cell treatment still counted as improved after a year, compared with 47.6% on placebo.
Immorta Bio says a person with advanced cancer in Mexico received its experimental treatment meant to help the immune system clear aging 'zombie' cells. No results have been reported yet.
Health records of more than 250,000 adults with prediabetes and obesity link Ozempic-style drugs to fewer cases of diabetes and heart problems than metformin. The findings are early and not yet peer reviewed.
A study of health records from more than 52,000 women in Israel, followed for 12 years on average, found similar rates of heart attacks, strokes, clots and early deaths with or without today's hormone therapy.
A UK study of 4,067 people around age 69 tied a quicker usual walking pace, timed in a test and by a wrist tracker, to lower death risk. It shows a link, not proof that speeding up adds years.
In a small early trial, a one-time eye injection paired with amber-light goggles made most of 10 people with an inherited blinding disease more sensitive to light. None regained normal sight.
An Australian coroner found Richard Norton went into cardiac arrest after injecting two unapproved peptides, and asked the drug regulator to consider limiting them to research.
Richard Norton3 sources · 5 minOld mice engineered to briefly switch on four 'Yamanaka' genes had smaller areas of brain damage and better movement scores two days after a stroke, a new study reports.
In a small Dutch diet study, 31 healthy adults aged 60 to 75 ate about two handfuls of roasted peanuts a day for 16 weeks. Memory areas of the brain then responded more strongly to insulin.
US regulators let start-up GenEditBio begin a first trial of a single eye injection that edits a faulty gene behind a group of inherited corneal diseases. No results have been reported yet.
Researchers trained AI on about 63,000 photos of the back of the eye to estimate 12 known Alzheimer's risk factors. Patterns differed in people diagnosed about 8.5 years later.
Using tiny human retinas grown in the lab, Johns Hopkins scientists report that a vitamin A molecule and thyroid hormone work together to build the eye's spot for sharpest sight.
Large studies of British and American adults link packing a week's exercise into one or two days with benefits similar to spreading it out, but none of them tested it directly.
Pfizer has teamed up with Edison Scientific to use its Kosmos AI system to help screen compounds, pick drug targets and design trials. No results from the work have been shared.
A 15-year study of more than 316,000 South Korean adults found that people at either end of the hemoglobin range on a routine blood test were more likely to be diagnosed with dementia.
Two targeted pills added to Keytruda shrank tumors in 70% of people with a gene-driven skin cancer. It also brought more serious side effects, and a survival gain is not yet confirmed.
In HER2-positive breast cancer, a type driven by a protein called HER2, patients whose tumors shrank fast on targeted drugs alone skipped chemo, and most stayed free of invasive disease for five years.
Pooled data on 2,684 older adults with no memory problems tied high levels of one blood marker to a much higher chance of decline, though the 10-year estimate rests on thinner data.
Elon Musk says Neuralink's Blindsight brain implant is ready from an engineering standpoint. No human results have been shown, and no trial start date has been announced.
Elon Musk4 sources · 5 minThe FDA granted accelerated approval to Inovio's Voceryq, a DNA-based treatment meant to reduce how often adults with a rare HPV-driven airway disease need surgery.
A review that pooled three small trials, 244 women in all, found testosterone did no better than a dummy treatment on memory and thinking tests after menopause.
Two weeks after starting a 600-man trial, Pelage has registered a separate study of its hair-regrowth gel in women with pattern hair loss, comparing it with a dummy gel.
Two trials in 691 adults, now in a major medical journal, found that Eli Lilly's weekly shot retatrutide cut nighttime breathing pauses far more than dummy shots.
Encoded Therapeutics says 21 young children with Dravet syndrome had fewer seizures and gained skills after a single gene therapy injection. The early studies had no comparison group.
In a 542-person trial, Acumen's antibody lowered amyloid plaque on brain scans but did not slow memory or daily-life decline, so the company is ending the drug's development.
Sumitomo Pharma says a surgeon at Kyoto University Hospital transplanted its donor-grown brain cells into a first patient in October, months after Japan's conditional approval.
Mice bred to build the twisted tau protein seen in Alzheimer's had fewer tangles after a century-old TB vaccine. The lead researcher says the result supports testing it in people.
A newly registered study will give tirzepatide to about 22 people and track whether blood-based estimates of how old their brain and other organs look change over six months.
In a year-long trial of 114 children, those taking an experimental pill grew about 6 cm a year versus about 4 cm on a dummy pill. Current approved treatments all need injections.
The FDA removed its strongest safety warnings from three estrogen patches for menopause without convening outside advisers or showing its evidence, and some experts object.
Robert F. Kennedy Jr.4 sources · 5 minThe American Geriatrics Society published a case-based guide for doctors on weight-loss drugs in older adults, centered on muscle loss, frailty, nutrition and what each patient wants.
Aspen Neuroscience sold shares on the Nasdaq stock market to fund work on a one-time brain cell treatment made from each patient's own skin cells. Its first human trial has 9 planned patients.
In 1,020 Korean adults followed for up to 8 years, those whose smoking, diet, exercise, drinking or sleep got worse scored older on DNA-based aging tests.
In a study of 585 healthy older adults, women who had used hormone therapy after menopause reported slightly faster-rising depression scores than men, but not compared with other women.
An NYU team aimed sound waves at a deep brain area in people with schizophrenia. Headlines said it calmed delusions. A critic points to a little-known journal and an undeclared company tie.
Two trials of an experimental cell therapy for an aggressive blood cancer were put on partial hold after some patients had serious nerve and brain side effects.
In a six-month trial of 136 older adults with memory problems and weak muscles, a formula with ginseng and the nutrient compound HMB was linked to small gains over a matched formula.
Researchers in the Netherlands, working with a Brazilian student, presented a simpler blood score built from ten routine markers that they say flags people at higher risk of heart disease, diabetes and stroke.
Researchers in Japan found a protein, OMC1, that helps egg cells hold on to the 'glue' keeping their chromosomes together for years. Without it, young mouse eggs made errors typical of old eggs.
Chicago surgeons put a wireless implant into the vision area of a third totally blind volunteer's brain. Results on what recipients can actually see have not been published.
Harvard researchers say pregnancy pushes up biological-age readings that partly fall back after birth, and a new pregnancy too soon might stop that recovery. It is still an untested idea.
Five years after a single dose of the CAR-T therapy Carvykti, 10 of 20 people with returning myeloma were alive with no sign of the cancer growing and no further treatment.
In 365 older adults at higher risk of Alzheimer's, a daily omega-3 pill raised levels in the fluid around the brain but did no better than a dummy pill on memory or brain shrinkage.
A new look at a big trial of 19,114 older adults found daily low-dose aspirin did not protect walking, strength, memory or mood. In women, scores fell a little faster than on a dummy pill.
A study of about 257,000 adults in US and UK health databases found statin users were diagnosed with dementia about twice as often, but it cannot show the pills were the cause.
The AI company behind Claude gave its most detailed look yet at its drug-research ambitions, including the idea of a 'one-person biotech'. No new medicines or test results were reported.
CereVasc says US regulators approved a study of its eShunt, a tiny implant placed through a vein that drains brain fluid, in people with early Alzheimer's symptoms.
A journal has published the placebo-controlled results of CervoMed's 159-person trial of neflamapimod. The pill did not beat placebo overall, and the company points to capsules that delivered too little drug.
Iovance says its immune cell therapy shrank tumors in 17 of 69 people with advanced lung cancer, and in 13 of 22 in a group it picked out afterward. Its shares fell sharply.
Baylor researchers matched 14 years of Fitbit step counts from 3,093 adults with brain tests and found more walking went with slightly better attention and self-control.
In an early study of 48 people, a single injection of Alnylam's experimental drug cut the harmful Huntington's protein for months. Whether that slows the disease is still untested.
Cleveland Clinic researchers link TMAO, a chemical gut bacteria make from parts of meat and eggs, to atrial fibrillation in 5,090 patients and push it in mice.
Vivex Biologics says 60% of people given an injection of donor spinal disc tissue had clearly less back pain at six months, compared with 1.6% after a fake procedure.
Mice born without cGAS, a protein usually linked to harmful inflammation in the aging brain, had weaker brain immune cells and worsening memory from early adulthood.
A Chinese study of 5,203 people aged 80 and up links eating meat almost every day to better odds of reaching 100, but only among the underweight, and it cannot show that meat is the cause.
ProPublica reports that ARPA-H director Alicia Jackson praised the end of strong warnings on menopause hormone therapy while holding stock in Evernow, the menopause care company she founded.
Copenhagen researchers say a drop in a fat inside muscle cells' power plants pushes aging muscle toward weaker but tougher fibers. The main tests were in mice.
More women, mostly of menopause age, are getting testosterone even though no US-approved version exists for them, and the evidence on benefits and heart risks is still unsettled.
In a 304-person trial, small-cell lung cancer patients watched with regular brain scans kept their thinking better than those given preventive brain radiation, with no clear survival loss so far.
A new look at a big Novo Nordisk trial found women lost about a quarter of their body weight on CagriSema before, during and after menopause, with lower blood sugar and blood pressure.
UCSF scientists built immune cells that stay switched off until they reach the brain. In mice they cleared a childhood brain tumor that almost always kills within a year. Human tests may start in 2027.
In a first safety test, scientists built a separate vaccine for each woman from her tumor's own mutations. Eight of 10 vaccinated patients showed an immune response, though the cancer still grew in some.
A 1972 UK law that raised the school-leaving age from 15 to 16 let researchers test whether schooling itself lowers dementia risk. The answer points one way, but how big the effect is remains unclear.
Harvard researchers moved ovaries from older mice into young ones. The organs looked younger on lab measures and the mice gave birth, in work not yet checked by outside experts.
A one-time dose of a ring-shaped RNA drug increased saliva in people left with dry mouth after head and neck cancer radiation. It is an early, 6-person study with no placebo group.
Benitec says every person treated with its one-time gene therapy for an inherited muscle disease that weakens swallowing met its response goals. The study is small and has no comparison group.
Yale researchers report that immune cells release the amino acid taurine when they sense danger, and that putting it back calmed a key inflammation switch in lab tests.
A Harvard-led team found a protein that makes old human skin cells look younger in the lab. In about 20 old mice, raising it cut frailty and lengthened median life.
George Church5 sources · 4 minA large trial of 699 people with advanced head and neck cancer reports longer survival when a two-target antibody was added to Keytruda. Full numbers have not been published yet.
The health department says it will not act against eligible pharmacies making BPC-157 and five other peptides while the FDA works on a formal rule. Its own scientists found too little evidence on them.
A 10-year study of 995 older Americans linked frequent and unplanned daytime napping to later dementia. The researchers say the naps may be an early sign of brain changes, not a cause.
University of Missouri researchers report that signals between nerves and muscles fail in weak older adults, and a drug approach from a Danish biotech improved strength in old rodents.
In a head-to-head trial in adults with type 2 diabetes, Eli Lilly says its weekly shot retatrutide led to 44 to 47 pounds lost versus about 21 on Ozempic.
New web guides published today say women on Ozempic-style drugs should stop well before trying to conceive. They disagree on how long, and none of them is a new official rule.
Cleveland Clinic doctors compared 178 eyes with late dry macular degeneration and found the damaged areas grew at a similar pace whether or not patients took AREDS eye vitamins.
In a trial against a placebo, older people with diabetic foot ulcers healed faster on the diabetes drug liraglutide, and blood signals from aging 'zombie' cells dropped.
In a 57-person trial, an experimental pill meant to calm brain inflammation did better than a dummy pill mainly in people with a high blood-platelet count.
In a trial of 1,106 men with very high-risk prostate cancer, adding the pill darolutamide (Nubeqa) lowered the risk of spread or death. It is too early to say whether men live longer.
A compound from broccoli made tiny lab roundworms live more than half again as long and look younger by a gene-activity measure, but only when the worms got it early in life.
In a test of 308 adults who stopped the weight-loss drug Zepbound, people given a one-time gut procedure regained less weight at six months than those given a fake one, the company says.
The FDA published draft rules that would speed approval of some gene therapies made for very small groups of patients. Rare disease advocates welcomed the move, but the plan is not final.
A Vienna team pooled gene data from more than 375,000 cells in 12 human tissues to show how the thin inner lining of blood vessels shifts as people get older.
A study of 2,928 Spanish speakers in Latin America found a computer estimate of age from speech ran older in people with dementia and tracked other measures of aging.
Artiva stopped its donor-made immune cell treatment for rheumatoid arthritis and related diseases after two deaths. It says neither was caused by the cells, and it will cut most of its staff.
Researchers measured thousands of proteins in the blood of over 2,000 older adults and found 17 linked to the risk of dying, several of which also tracked how old organs seemed.
A University of Hawaii study matched gut bacteria to a blood measure of how fast people age. Some microbes went with slower aging and others with faster aging, but the study cannot show cause.
Beam Therapeutics says a single infusion of its gene-editing treatment let two people with a rare blood sugar disease fast for 15 hours and drop starch doses. Serious side effects hit 4 of 6.
Europe cleared Enhertu for some HER2-positive breast cancer patients after surgery, based on a big trial where it cut the risk of cancer returning or death by 53% versus an older drug.
In 2,109 men with aggressive prostate cancer, adding the pill Erleada for six months before and after surgery lowered the risk of spread or death by 20%, with more side effects.
Seven Mayo Clinic studies look at why worn-out 'zombie' cells keep fueling inflammation as we age. They also test ways to target them, including a compound found in tomatoes, so far in older mice.
João Passos7 sources · 5 minA one-time cell therapy grown from patients' own tumor immune cells, approved in the US for melanoma, shrank tumors in 4 of 8 people with two hard-to-treat sarcomas in an early trial.
Trade press reported that a Merck drug, which carries chemotherapy straight to tumor cells, lowered the risk of death by 32% versus standard chemotherapy in women whose womb cancer came back after earlier treatment.
A virtual biotech with no human staff combed past trials for clues to which drugs succeed, then proposed a lung cancer drug idea a real drugmaker later pursued on its own.
US regulators cleared Pfizer's Talzenna with Xtandi for men whose spread prostate cancer still responds to hormone therapy and carries DNA-repair gene flaws.
In a study of 35,878 adults, adding Grail's Galleri blood test to routine screening found far more cancers, but it had no comparison group, so it cannot show fewer late cancers or deaths.
Indianapolis startup Carnyx says its experimental pill added about 1.5 to 2 hours of sleep in old rats, mostly deeper sleep, and has hired a doctor to plan human tests.
A small Mayo Clinic study will give 20 people with early Parkinson's five short sessions of very low-dose radiation to see whether calming brain inflammation slows the disease.
Warhound, tied to Colossal Biosciences and Anduril, says it will edit and clone top military and police dogs to cut inherited disease. No dogs have been born yet.
Ben Lamm3 sources · 4 minInsilico Medicine says its daily pill, built with generative AI, shrank mesothelioma tumors in 2 of 5 assessed patients at the highest dose tested so far, in a first test in 36 people.
Alex Zhavoronkov6 sources · 5 minIovance told a major cancer meeting that its tumor immune cell treatment shrank tumors in half of 8 people with two hard-to-treat sarcomas, and none of those tumors had grown back yet.
A new study in an Alzheimer's journal links daily low-dose aspirin to less dementia in older people, but large earlier trials found no benefit and more bleeding.
In aged rats, two weeks of an experimental drug reopened tiny filter holes in liver cells and brought an Alzheimer's-linked protein and 'bad' cholesterol down to young levels.
Britain's medicines regulator approved Leqselvi, a tablet that calms part of the immune system, for adults with severe alopecia areata. In trials, about 3 in 10 regrew most of their scalp hair in 24 weeks.
A study in The BMJ found more hair loss in people with diabetes who started Ozempic-style drugs, and a hair specialist asks whether the shedding is always temporary.
Bristol Myers Squibb reported that 66 people with hard-to-control MS got a one-time engineered immune cell treatment. Most stayed stable off their usual drugs, and one patient died.
AstraZeneca's targeted drug helped people with advanced stomach cancer live months longer than standard treatment in a 532-person trial, but it missed its goal of slowing tumor growth.
A mouse study in the journal Cell found that cutting calories by 30% lowered the number of DNA mistakes cells pile up with age, but not equally in every organ.
In a 338-person trial, Roche's daily pill divarasib was tested directly against two approved drugs for the same gene change in lung cancer. Half of patients on it lived at least 17.7 months, against 12 months on the older drugs.
Eli Lilly has registered two large trials of a shot that pairs the drug in Zepbound with a fullness-hormone drug. The open question is how many people can stay on it.
In a mid-stage trial of a one-time cell therapy given with Keytruda as a first treatment, tumors disappeared on scans in about 29% of people with advanced melanoma.
Researchers read nearly complete DNA from eight closely related bats and found that genes shaped by viruses overlap with genes tied to DNA repair, cancer and lifespan.
Juan Manuel Vazquez7 sources · 5 minIn a trial of nearly 10,000 healthy Australians over 70, a daily statin lowered heart attacks, strokes and related events by about 30%, but people did not live longer free of dementia or disability.
In 31 boys with Duchenne, a single infusion got muscles making a stand-in for a missing protein above a target level. Early walking and standing tests favored treatment.
In a 563-person trial, people with advanced small cell lung cancer who got Amgen's Imdelltra on top of Imfinzi lived a median 21.1 months, against 12.7 months on Imfinzi alone.
A vaccine built from each patient's own tumor, given with the immune drug Keytruda, lowered the chance melanoma came back or killed patients in a 1,137-person trial.
Georgina Long9 sources · 5 minLab results from over a million women suggest bones, liver and blood fats shift sharply around the last period, with hormone changes starting more than a decade earlier.
Uri Alon4 sources · 5 minBristol Myers Squibb says one person with multiple sclerosis died of a lung infection 44 days after its experimental cell therapy, weeks after the company paused enrollment.
A mouse study in Cell Metabolism suggests bone's ability to sense physical force carries some of exercise's anti-aging effect. Loading the shin bone of old mice extended their lives by about 80 days.
Chinese company XellSmart says donor-derived brain cells implanted in nine people with Parkinson's improved movement scores at six months, with no serious side effects. No comparison group was used.
Two Wisconsin sisters and a brother and sister treated in Cincinnati are hearing sounds after a one-time gene therapy for a rare inherited deafness. It is still unknown how long the effect lasts.
A preventive health clinic used AI to read routine heart scans and says it found inflamed arteries in many people whose blood tests looked fine. No paper or headcount has been released.
The US drug regulator has set up a brain-disease program whose first job is to rethink how Alzheimer's prevention studies pick volunteers and measure decline.
A federal health agency is funding a four-year national study, led from Mass General Brigham, that will use blood tests to quickly sort through 5 to 10 drug and plant-compound combinations.
Rudolph Tanzi5 sources · 5 minA Bonn team turned blood cells from older donors into stem cells that can make brain cells. Lab measures of aging dropped by decades, slowly enough to watch it happen.
Loyal's daily pill for dogs aged 10 and up has cleared two of the three FDA reviews needed for conditional approval. Results from its large trial are not out yet.
A Nature study in tiny worms traces how cool temperatures lengthen life: muscles make a molecule called BH2 that travels to the gut and nerves and helps keep proteins from clumping.
The FDA has approved GSK's Hibsago, a six-month course of injections. In two large trials, about 1 in 5 people kept the virus in check after stopping all hepatitis B drugs.
In a six-month study of 536 men, a slow-release pill version of minoxidil, the active ingredient in Rogaine, grew more hair than a dummy pill. The results come from the company and have not been independently checked yet.
In a trial in adults with HIV, people given semaglutide (Ozempic, Wegovy) aged more slowly on DNA-based 'aging clocks' than people given dummy shots. The analysis was done after the trial ended.
A UK biotech has treated the first of 36 people with Parkinson's in a trial of a pill designed to help brain cells remove their damaged power plants. First results are expected in late 2027.
In its first menopause update since 2014, the main US group of women's health doctors says hormone therapy should be a first choice for hot flashes, night sweats and the sleep problems they cause.
The FDA has sent the White House a draft plan that reportedly would let pharmacies mix some unapproved peptides, including ones the agency has flagged for possible safety risks.
Pelage Pharmaceuticals has treated the first man in a year-long trial of its scalp gel for pattern baldness. The gel is meant to restart resting hair stem cells, but the evidence so far is thin.
Three years after a tiny chip was placed under the retina of people with advanced dry macular degeneration, the sight it gave back has not faded among the 18 patients still tested.
Korean biotech PRG S&Tech has begun enrolling adults with Werner syndrome, a rare genetic disease that brings on aging decades early, in a US trial of its drug Progerinin.
Natera says the FDA gave its multi-cancer screening blood test a Breakthrough Device designation. It is not an approval, and the company has published no accuracy numbers.
A map of 12.4 million blood immune cells from 2,609 adults finds that people whose immune systems lean toward one kind of 'killer' cell had more illness and deaths years later.
A study of 894 pet dogs found that large breeds and male dogs pile up age-linked chemical changes on their DNA faster, which may help explain why they tend to die younger.
The longevity entrepreneur, who said in June that his immune system is attacking his stomach, told The Axios Show that AI is still too error-prone to trust with health.
Bryan Johnson3 sources · 5 minIn a year-long study of 410 people with early Parkinson’s, the supplement nicotinamide riboside (NR) raised a molecule cells use for energy, but did not slow the disease. Symptoms got slightly worse than on a dummy pill.
Charalampos Tzoulis7 sources · 5 minNovo Nordisk and Eli Lilly told an aging conference that people taking semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) appeared to age more slowly on lab estimates of biological age. Nothing has been peer reviewed yet.
Three people with glaucoma had no serious side effects in the eight weeks after a single eye injection, and two showed some improvement in their field of vision, Life Biosciences said. It is a very early, company-reported result.
A study of Jonathan, the giant tortoise on St. Helena, found that the switches controlling his cells' energy genes still look like those of young tortoises.
In a 10-person study, a one-time eye injection paired with camera goggles made light detectable again for most patients with an inherited blindness, but none regained normal sight.
Prime Medicine says the first person has received a one-time infusion that aims to repair the gene behind Wilson's disease, a rare illness that lets copper build up in the body.
UK and German scientists switched on a cell's built-in fuel gauge with an experimental drug and saw longer lives in three lab species, in some cases by about a quarter. No mammals have been tested yet.
In a small University of Missouri pilot study, four weeks of low-dose rapamycin raised brain blood flow in healthy middle-aged carriers of the main Alzheimer's risk gene, most of all in women.
In 31 people with a severe form of fatty liver disease, a leukemia pill paired with a compound found in onions and apples eased liver scarring more often than a dummy pill over 21 weeks.
In a small group from Nektar's trial for autoimmune hair loss, most people who regrew hair on its injected drug kept it six months after stopping, the company and a trial doctor reported.
NewAmsterdam Pharma has given the first dose in a 400-person, placebo-controlled test of its cholesterol pill in older adults who show early Alzheimer's signs in tests but have no memory problems yet.
At a longevity meeting in Boston, senior FDA officials said aging will feature in an upcoming planning report and sketched how a drug aimed at aging might one day be approved.
New data from 12 people given a one-time brain gene therapy show slower loss of daily function than in untreated outsiders, but the gap narrowed and the comparison has gaps.
Cochlear says it has signed up all 92 adults for two big tests of a cochlear implant that sits fully under the skin, with first safety and hearing results planned at six months.
Year-long trial data on a hormone-blocking scalp solution for male pattern hair loss show side effects similar to a dummy solution and a small rise in hair density.
In a trial of 85 boys and men with an inherited blinding disease, a one-time gene injection beat no treatment on a dim-light reading test, its maker Beacon says.
In 15 people whose cholesterol stayed high despite medicines, one infusion of a gene-editing treatment kept LDL and blood fats about 50% lower a year later at the highest dose.
US regulators extended Lilly's Olumiant, a once-daily pill already used by adults, to people aged 12 and up with severe alopecia areata, after a trial built for teenagers.
A Berkeley-led study in Nature found that semaglutide, the drug in Ozempic and Wegovy, lengthened life in elderly female mice and beat a matched diet on memory and blood sugar.
A split FDA expert panel sided with Grail's Galleri blood test for people 50 and older. Panel members still worried about missed cancers, false alarms and whether it saves lives.
Roche's PrevenTRON study will give an experimental antibody or a placebo (a dummy treatment) to about 1,600 people aged 55 to 80 who have no memory problems but carry a blood marker linked to Alzheimer's.
Fayuvi, a one-time infusion for children with Sanfilippo syndrome type A, won US approval after families spent years raising money to keep the early research alive.
In a first test in people, broken bones became far less frequent after 10 women received their own sugar-tagged marrow cells, but the trial had no comparison group and most also took standard bone drugs.
Apple's redesigned Health app will compare your body's measurements with your real age and let US users book lab blood tests from an iPhone. Critics question what such scores mean.
Bryan Johnson5 sources · 5 minIn 42 people with a scarring lung disease, six separate blood-protein aging tests all read younger on an experimental AI-designed drug. The split dose gave the steadiest signal, and the result is not proof it slows aging.
Alex Zhavoronkov10 sources · 6 minNovartis says its monthly shot lowered Lp(a), an inherited fat particle in the blood, but did not reduce a combined count of serious heart problems in 8,323 people.
A spinal injection given every three months is now the first approved treatment aimed at the cause of Alexander disease, a genetic brain disorder that affects fewer than one in a million people.
uniQure has asked US and UK regulators to approve its one-time Huntington's gene therapy. The request rests on small early trials compared with untreated patients from outside the studies.
Ocugen has treated the first person in a 237-person trial of a one-time gene therapy for geographic atrophy, a late form of dry macular degeneration, and says it plans to seek US approval in 2028.
Three patients died after a severe immune reaction to Novartis's engineered immune cell therapy. Bristol Myers Squibb also paused enrollment in trials of a similar treatment.
At least 30 people had fever, chills and sepsis-like symptoms after IV drips of glutathione, a 'detox' supplement. The FDA traced the powder to one supplier and warned pharmacies.
Andrew Steele7 sources · 6 minIn two large trials paid for by its maker AbbVie, about half of people with severe alopecia areata on the arthritis pill Rinvoq got back most of their scalp hair in 24 weeks.
Retro Biosciences is adding 32 healthy volunteers to its first safety test of a pill meant to help brain cells clear out waste, after early doses caused no major side effects.
The daily pill targets RAS, a cancer-driving protein long called 'undruggable'. In a 500-patient trial, people on it lived a median of 13.2 months versus 6.7 on chemotherapy.
The European Commission cleared AbbVie's daily pill Rinvoq for adults and teens with severe alopecia areata, an immune disease that makes hair fall out, based on two large maker-run trials.
Lab work at the Buck Institute suggests the rare APOE2 gene version helps brain cells avoid and repair DNA damage. Memory was not part of what was reported.
In a July vote that FDA staff opposed, outside advisers recommended that pharmacies be allowed to mix six popular peptides, including BPC-157. The FDA has not decided yet.
Absci says its antibody shot for pattern hair loss caused no serious side effects in 32 healthy adults and may need only two or three doses in six months. Hair-growth results are still to come.
Researchers at MD Anderson say aging cells push a tangled piece of genetic material out of their core, setting off an alarm that won't switch off. A cancer drug blocked it in preclinical models.
The FDA now allows bemotrizinol, a UV filter long sold in Europe, in US sunscreens. It is the first new active ingredient added to the US sunscreen list since 1999.
Robert F. Kennedy Jr.4 sources · 5 minNewLimit, co-founded by Coinbase's Brian Armstrong, raised $435 million to bring a drug meant to make old liver cells act younger into its first human test, planned for 2027.
Oura added a tool for people on Ozempic-style drugs that keeps doses, side effects and weight next to ring data. The company has not published evidence that it changes outcomes.
A San Diego company says a stem cell treatment helped many dogs and cats with arthritis in small pilot studies. It hopes for US approval in 2028.
A study in Nature compared people's reported sleep with 23 'aging clocks'. Both short and long sleepers looked older inside, and those sleeping about 6.4 to 7.8 hours looked youngest.
A news report says short daily bursts of vigorous activity, like running for a bus, may cut the risk of eight diseases and death. The study behind it could not be checked.
A Berkeley Lab team that grew breast cells from women aged 16 to 91 found aging tilts the cell mix toward types linked to cancer. The link to actual tumors was not shown.
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Memory, Alzheimer's, Parkinson's and keeping the brain sharp with age.
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Ozempic-style drugs, diabetes, blood sugar and how weight and metabolism shape aging.
The biology of aging and the research trying to slow or reverse it: cell rejuvenation, worn-out "zombie" cells, aging clocks and lifespan studies.
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Vision and hearing loss with age, and the treatments trying to save or restore them.
Menopause, testosterone and other hormones, and how they affect aging in women and men.
FDA and other regulators, laws and policy shaping longevity medicine.
Heart disease, blood pressure, cholesterol and the treatments that protect the heart and blood vessels.
Osteoporosis, arthritis and muscle loss with age, and what keeps people strong and mobile.
Popular longevity supplements and compounds, read for what was actually measured and in whom.
Biological age tests, blood panels, scans and wearables: what they measure and how much to trust them.
Reproductive aging, egg and sperm health, and new fertility science.
The aging immune system, chronic inflammation, vaccines and infections in later life.
How AI is being used to find drugs, design treatments and measure aging.
Drugs and research aimed at helping dogs and cats live longer, healthier lives.
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What studies say about training, strength, endurance and movement for a longer, healthier life.
Sleep and aging: research on how much, how well, and what improves it.
Diets, fasting, calorie restriction and what eating patterns do to health and aging.
Big new trials of longevity and age-related treatments: what started, what finished and what the numbers say.
The companies, money and deals behind the longevity industry.
Research on the bacteria and other microbes living in the gut and how they relate to digestion, disease and aging.
First-of-their-kind results that change the outlook for a disease.
Skin aging, wrinkles, sun damage and what the evidence says about treatments that claim to help.
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What the best-known self-experimenters are doing, measuring and claiming, separated from what has been tested.
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A mouse study, a company claim and a randomized trial are not the same thing. Each story says which one it is.
We don’t tell you what works. We report what was measured, in whom, and what is still unknown.
David Sinclair
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